Chemoenzymatic Dynamic Kinetic Resolution of Sterically Hindered Allylic Alcohols under Mild Conditions: A Synthetic Route to Enantiomerically Enriche

K. BOGAR, PILAR HOYOS VIDAL, ANDRÉS R. ALCÁNTARA LEÓN, JAN-E. BÄCKVALL

Abstract
Dynamic kinetic resolution (DKR) of a series of sterically hindered allylic alcohols has been conducted with Candida antarctica lipase B (CALB) and ruthenium catalyst 1. The optically pure allylic acetates obtained were subjected to oxidative cleavage to give the corresponding acylated acyloins in high yields without loss of chiral information.

http://pubs.acs.org/doi/abs/10.1021/ol071395v